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A beautiful image. Does this cary an increased cancer risk? Thanks for the great posts!

----Comment by: PathDoc15 on 5/17/2009 9:16:45 AM

It is unclear what the cancer risk is. This is a very unusual lesion so it is hard to get a series of sufficient size to be meaningful. There probably is some risk based on several reports of associated and subsequent cancers, but the numbers are very small and no systematic study has been done. Current management is complete excision and close follow up.

----Comment by: KingBent on 5/18/2009 6:49:32 AM

Juvenile papillomatosis (JP) is a breast tumor of young women featuring atypical papillary duct hyperplasia and numerous cysts, first described as a clinicopathologic entity in 1980. The disease is of interest because of the youth of these patients and the fact that the pathologic elements resemble those considered to be precancerous in older women. JP is a marker for families at risk and now indicate that the patient with JP may herself be in jeopardy of developing breast cancer coincidentally or at a later date. Wide local excision is adequate to control the lesion in most cases. Careful clinical surveillance is indicated for any woman who has juvenile papillomatosis and for her female relatives. The early age of onset of this unusually florid proliferative disease, and family history association, suggest there may be an underlying hormonal disturbance or genetic abnormality.

----Comment by: avrege15 on 12/22/2010 7:50:37 PM


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