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I can think of three lesions which are typical centered on the epiphysis - can you?

----Comment by: PathDoc15 on 12/17/2008 12:32:05 PM

Wait, you mean to tell me that I can not use the finding of Giant cells to help me in this differential? It appears that all of these tumors have them.

----Comment by: Iago on 12/17/2008 7:48:51 PM

Lesion #1: Clear cell chrondrosarcoma.

----Comment by: PathDoc15 on 12/20/2008 2:57:20 PM

Lesion 2 Chondroblastoma.

----Comment by: kyouens on 3/10/2009 8:32:57 PM

So, you don't like my diagnosis?

----Comment by: PathDoc15 on 3/17/2009 2:24:40 PM

Iago - opinion? (also we need some tags...)

----Comment by: PathDoc15 on 3/17/2009 2:26:01 PM

If the diagnosis had to be made on this field alone, I think that clear cell chondrosarcoma would be more appropriate. Cytologically, the clear cell features here are sticking. Also, the nuclear features are not consistent with chondroblastoma. Classic nuclear features of the latter include nuclear groves. The cells also have what has been described as a "fried-egg" appearance because of the abundent cytoplasm. These nuclei have vesicular chromatin with prominent irregular nucleoli.

----Comment by: Iago on 3/21/2009 2:08:01 PM


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