| Additional Info: |
This low power view of a lymph node shows complete effacement of the normal lymph node architecture and paler regions with medium sized to larger cells (prolymphocytes and paraimmunoblasts). This histologic appearance coupled with a characteristic (but not 100% specific or sensitive) surface antigen profile (CD5 positive, CD23 positive, Surface Ig weak). CLL lacks the t(11;14) an associated cyclin D1 overexpression seen in mantle cell lymphoma(the other CD5 lymphoma). |