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BigDaddy - Help me out a little here. What IHC would you suggest for germ cell tumor of the testis to get to the diagnosis of embryonal carcinoma? Did CD30 alone get you there on this case? Anyway, another great one. And a special request, have you got a lower power shot?

----Comment by: PathDoc15 on 2/28/2007 4:53:43 PM

PLAP would be positive also, and if it was mixed (with chorio or yolk sac elements) it might have HCG or AFP.

----Comment by: kyouens on 2/28/2007 6:54:18 PM

Embryonal carcinoma is the only germ cell tumor which is CD30 positive (that I know of ), so that goes a long way toward the diagnosis when the staining is strong and diffuse in a membranous pattern. Cytokeratin was also positive in this case, but that does not rule out embryonal (something like 1 3 of cases stain positively for panCK). Overall, the mix of solid and glandular morphology with the high grade, almost syncytial quality of the cells leads to the diagnosis...IHC is just confirmatory.

----Comment by: BigDaddy on 2/28/2007 7:17:11 PM

     

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