Question of the Day

Concerning KIT mutations in malignant melanoma which of the following statements are true (as of 1/1/2009)?
The KIT mutations that occur in melanoma are largely the same as those seen in the majority of GI stromal tumors
Individual case reports have show a major/complete response to imatinib in patients with metastatic melanoma which harbor KIT mutations
The KIT mutations in malignant melanoma are inactivating mutations (loss of a tumor supressor gene)
Multi-center Phase II clinical trials have demonstrated a clinical benefit to treating melanoma patients with imatinib.

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