Question of the Day

Case Study: 25 year old female with right lower extremity pain and swelling. Imaging studies reveal a deep vein thrombosis. She is otherwise healthy and her only risk factor for thrombosis is oral contraception. Given this history, all of the following are true, EXCEPT?
Hypercoagulability due to Factor V mutations is dosage dependent with disease manifestation in both heterozygotes and homozygotes.
A mutation in Factor V can be found in approximately 20% of patients with this clinical picture. (Glu 506 Arg).
The population (European descent) frequency of Factor V (Glu 506 Arg)is 0.1 to 0.2%.
Factor V (Glu 506 Arg) is relatively resistant to proteolysis by protein C.

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