Question of the Day

Case Study: 40 year old male with an insidious onset of mild anemia, fatigue, weakness, weight loss, and splenomegaly. Routine labs show a very high peripheral white count consisting of PMN’s and immature granulocytes including a predominance of promyelocytes. Given the most likely diagnosis, all of the following are true, EXCEPT?
This disease is associated with a specific chromosomal translocation: t(9;22)(q34;q11).
The fusion protein produced in this disease is identical to that in a small percentage of B-ALL (3% of pediatric and 20% of adult).
The translocation associated with this disease produces a fusion protein consisting of the 5’ end of BCR and the 3’ end of ABL that can be detected by a simple PCR reaction.
Cytogenetic analysis can provide unique information on top of PCR or interphase FISH for the evaluation of this disease, and remains essential in initial evaluation and follow up.

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